Yes, many freelancers and side hustlers can qualify for business credit cards, even without a formal incorporated company.
What issuers usually care about
Issuers typically care more about whether you have legitimate business activity than whether you have a giant company. Selling online, freelance work, contract services, and consulting income can all count.
Why people open them
Business cards can help separate expenses, unlock different reward categories, and keep business-related purchases easier to review at tax time.
Bottom line
If you have real freelance or side-hustle activity, a business card may be a reasonable tool, provided you keep spending organized and personal balances controlled.